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  • Title: Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration.
    Author: Starfinger C, Chase JG, Hann CE, Shaw GM, Lambermont B, Ghuysen A, Kolh P, Dauby PC, Desaive T.
    Journal: Math Biosci; 2008 Dec; 216(2):132-9. PubMed ID: 18817788.
    Abstract:
    A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N=6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.
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