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  • Title: Kidney transplantation improves sleep-related breathing in hemodialysis patients.
    Author: Jurado-Gámez B, Martin-Malo A, Rodriguez-Benot A, Muñoz-Cabrera L, Cosano Povedano A, Aljama P.
    Journal: Blood Purif; 2008; 26(6):485-90. PubMed ID: 18818490.
    Abstract:
    AIMS: To assess whether kidney transplantation improves sleep-related breathing disorders associated with hemodialysis. METHODS: A prospective study was carried out using full-night polysomnography. Nine hemodialysis patients (7 men and 2 women, aged 42 +/- 16.2 years, BMI 26 +/- 3.7) who later received a successful kidney transplantation were evaluated. Main sleep quality and respiratory variables were recorded: number of dips in oxygen saturation (SaO(2)) > or =3% per hour of sleep; percentage of sleep time with SaO(2) <90%; percentage of sleep time in apnea and hypopnea, and sleep apnea/hypopnea index (AHI). RESULTS: After kidney transplantation, the AHI improved in 8 of the 9 patients (10 +/- 10.7 vs. 4.9 +/- 6.1, p = 0.029). A decrease in the percentage of sleep time in apnea/hypopnea (5 +/- 6.8 vs. 0.7 +/- 1.1%, p = 0.008) and a reduction in the number of desaturations (25 +/- 26 vs. 12 +/- 11.2%, p = 0.010) were observed. CONCLUSIONS: Kidney transplantation improved respiratory events and nocturnal SaO(2) in hemodialysis patients.
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