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  • Title: [Contribution of rennin-angiotensin-aldosterone system genes and NO synthase gene to the development of arterial hypertension].
    Author: Savinetskaia GA, Golubeva AA, Pogoda TV, Generozov EV.
    Journal: Klin Med (Mosk); 2008; 86(8):12-7. PubMed ID: 18819340.
    Abstract:
    Arterial hypertension (AH) is one of the most widespread cardiovascular disorders, 39.2% of men and 41.1% of women having elevated arterial pressure (AP). Hence, the necessity to elucidate possible causes of this abnormality. Heredity is considered to be a major factor determining AP in humans, and researchers all over the world are engaged in the search for AP markers. This paper is focused on genes controlling the renin-angiotensin-aldosterone system, viz. genes of angiotensin II, type 1 angiotensin II receptors, angiotensin-converting enzyme, and NO synthase. An overview of population studies with special reference to these genes indicates that molecular-genetic mechanisms of AH remain unclear. Joint efforts of researchers working in different centres are needed to address the problem.
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