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  • Title: [Effect of the sera of rabbits fed with Tongxinluo on MMP-9 and TIMP-1 expression and secretion in U937 monocyte-derived macrophages].
    Author: Liu JL, Zhu QF, Hao BS.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2008 Aug; 28(9):1703-6. PubMed ID: 18819903.
    Abstract:
    OBJECTIVE: To investigate the effect of the sera of rabbits fed with Tongxinluo on the expression and secretion of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in U937 monocyte-derived macrophages. METHODS: Atherosclerosis was induced in rabbits by high-cholesterol feeding, and the serum was obtained from the rabbits after administration of the aqueous solution of Tongxinluo or simvastatin by gavage. U937 monocyte-derived macrophages were incubated with the sera at different concentrations for 24 hours, and the changes in MMP-9 and TIMP-1 gene expression and secretion were detected by RT-PCR and enzyme-linked immunosorbent assay, respectively. RESULTS: The serum of rabbits fed with Tongxinluo concentration-dependently inhibited the expression and secretion of MMP-9 in U937 macrophages, but did not affect TIMP-1 expression or secretion. CONCLUSION: Tongxinluo may stabilize the atherosclerotic plaques by inhibiting the expression and secretion of MMP-9.
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