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  • Title: Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro.
    Author: Kim SH, Jang SD, Lee KY, Sung SH, Kim YC.
    Journal: J Enzyme Inhib Med Chem; 2009 Feb; 24(1):230-3. PubMed ID: 18825536.
    Abstract:
    A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-beta-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 microM.
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