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  • Title: Melatonin and its agonists: an update.
    Author: Arendt J, Rajaratnam SM.
    Journal: Br J Psychiatry; 2008 Oct; 193(4):267-9. PubMed ID: 18827285.
    Abstract:
    The pineal hormone melatonin is able to shift the timing of circadian rhythms, including the sleep-wake cycle, and to promote sleep. Melatonin agonists with similar properties have therapeutic potential for the treatment of circadian rhythm sleep disorders. Depression is specifically targeted by agomelatine, which is also a serotonin-2C (5-HT(2C)) antagonist.
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