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  • Title: Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients.
    Author: Hoehn-Saric R, Pearlson GD, Harris GJ, Machlin SR, Camargo EE.
    Journal: Am J Psychiatry; 1991 Sep; 148(9):1243-5. PubMed ID: 1883007.
    Abstract:
    Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.
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