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  • Title: BiovaxID, a personalized therapeutic vaccine against B-cell lymphomas.
    Author: Reinis M.
    Journal: Curr Opin Mol Ther; 2008 Oct; 10(5):526-34. PubMed ID: 18830928.
    Abstract:
    Biovest International Inc (a subsidiary of Accentia BioPharmaceuticals Inc), under license from Stanford University, is developing BiovaxID, a personalized therapeutic vaccine against B-cell lymphomas that, in combination with GM-CSF, exclusively targets cancerous B-cells by raising an immune response to tumor-specific immunoglobulin proteins called idiotypes, for the potential treatment of follicular non-Hodgkin's lymphoma (NHL). Phase I and II clinical trials demonstrated the immunogenicity, safety and therapeutic efficacy of BiovaxID. Phase III clinical trials in NHL were ongoing at the time of publication.
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