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  • Title: Iodocyclization of ethoxyethyl ethers to alkynes: a broadly applicable synthesis of 3-iodobenzo[b]furans.
    Author: Okitsu T, Nakazawa D, Taniguchi R, Wada A.
    Journal: Org Lett; 2008 Nov 06; 10(21):4967-70. PubMed ID: 18831555.
    Abstract:
    A wide variety of 3-iodobenzo[b]furans were readily prepared by iodocyclization of 2-alkynyl-1-(1-ethoxyethoxy)benzenes with the I(coll)2PF6-BF3 x OEt2 combination. Aryl-, vinylic-, and alkyl-substituted alkynes undergo iodocyclization in good to excellent yields. The mechanism of the reaction is also discussed.
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