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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
    Author: Hollingsworth NM.
    Journal: Genes Dev; 2008 Oct 01; 22(19):2596-600. PubMed ID: 18832063.
    Abstract:
    The transition from pachytene to Meiosis I is a key regulatory point in yeast meiosis. This transition requires Ndt80, a transcription factor that commits cells to complete meiosis by expression of a diverse set of genes. In this issue of Genes & Development, Sourirajan and Lichten (2627-2632) report that CDC5, an NDT80-regulated gene encoding yeast polo-like kinase, is sufficient for Holliday junction resolution and exit from pachytene. Determining the meiotic targets of Cdc5 therefore provides a new approach for identifying a eukaryotic Holliday resolvase.
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