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  • Title: Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan.
    Author: Hotomi M, Billal DS, Kamide Y, Kanesada K, Uno Y, Kudo F, Ito M, Kakehata S, Sugita R, Ogami M, Yamanaka N, Advanced Treatment for Otitis Media Study Group (ATOMS).
    Journal: J Clin Microbiol; 2008 Nov; 46(11):3808-10. PubMed ID: 18832131.
    Abstract:
    Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan.
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