These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: DCX and PSA-NCAM expression identifies a population of neurons preferentially distributed in associative areas of different pallial derivatives and vertebrate species.
    Author: Luzzati F, Bonfanti L, Fasolo A, Peretto P.
    Journal: Cereb Cortex; 2009 May; 19(5):1028-41. PubMed ID: 18832334.
    Abstract:
    In adult rodents, doublecortin (DCX) and polysialylated neural cell adhesion molecule (PSA-NCAM) expression is mostly restricted to newly generated neurons. These molecules have also been described in prenatally generated cells of the piriform cortex and, to a lesser extent, neocortex (NC) of the rat. In addition, PSA-NCAM+ cells have been identified in several telencephalic regions of the lizard. Here, through immunohistochemistry and 3-dimensional reconstruction, we have investigated distribution, morphology, and phenotype of DCX/PSA-NCAM-expressing cells in the pallium of different mammals and in lizard. In all species, a population of nonnewly-generated pallial DCX+/PSA-NCAM+ cells shows common morphological and phenotypic characteristics, including expression of Tbr-1, a transcription factor expressed in pallial projection neurons, and preferential distribution in associative areas. In the guinea pig and rabbit, DCX+/PSA-NCAM+ elements are also abundant in the NC, particularly in areas implicated in nonspatial learning and memory networks. In reptiles, DCX+/PSA-NCAM+ cells are located in the lateral and medial cortex and dorsal ventricular ridge but not in the dorsal cortex. These data support the fact that coexpression of DCX+/PSA-NCAM+/Tbr-1+ in the adult brain identifies evolutionary conserved cell populations shared by different pallial derivatives including the mammalian NC.
    [Abstract] [Full Text] [Related] [New Search]