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  • Title: Antidepressant effects of high-dose right unilateral electroconvulsive therapy.
    Author: Abrams R, Swartz CM, Vedak C.
    Journal: Arch Gen Psychiatry; 1991 Aug; 48(8):746-8. PubMed ID: 1883258.
    Abstract:
    In a random-assignment, double-blind, controlled comparison in 38 melancholic men, overall antidepressant potency of high-dose electroconvulsive therapy (378-mC charge) given with right unilateral electrode placement was not significantly different from that with bilateral placement, although there was a trend for faster improvement with bilateral ECT. The suprathreshold character of the stimulus, about 2.5 times the expected seizure threshold, may have contributed to the high efficacy of brief-pulse right unilateral electroconvulsive therapy found in this study.
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