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  • Title: Benign hepatic tumors and oral contraceptive pills.
    Author: Kalra TM, Mangla JC, DePapp EW.
    Journal: Am J Med; 1976 Dec; 61(6):871-7. PubMed ID: 188336.
    Abstract:
    In order to consider possible environmental factors related to the development of benign hepatic tumors, all reports of this disorder in the case records of five different hospitals in Rochester, New York, during the past 10 years were reviewed. Seven patients with benign hepatic tumors of the liver and two with peliosis hepatis were identified. Among the seven with a benign hepatic tumor, four were women currently receiving oral contraceptives; one had been receiving this medication in the past, and two had no history of exposure to any steroid whatsoever. The two patients with peliosis hepatis were receiving long-term androgenic anabolic steroids. Dilated, thin-walled vessels and vascular spaces were a more prominent feature of the tumor seen in four patients receiving oral contraceptive pills. It is emphasized in this report that benign hepatic tumors do occur in men and in patients with cirrhotic liver without the use of any kind of steroids. All cases of benign liver cell tumors seen during the past 10 years (1964-1974) at 5 hospitals in Rochester, New York, were reviewed to determine if any relationship with the ingestion of oral contraceptives, or other related steroids, could be shown. There were 7 patients with benign liever tumors and 3 with peliosis hepatis. These lesions were of 3 different histopathologic types. They included hepatic adenoma and focal nodular hyperplasia. The 3rd type of lesion, peliosis hepatis, involves the liver as multiple blood-filled spaces. In 2 of the cases of peliosis haeptis the patients were receiving long-term androgenic anabolic steroids; 1 was a man. Among the 7 patients with benign hepatic tumors, 4 were currently receiving oral contraceptives and 1 had formerly done so. There were 2 patients who had never received any kind of oral contraceptive pill or any other similar steroids. A cirrhotic liver was present in 1 of them. Individual case histories are given. It is emphasized that oral contraceptive use is not the only cause of these tumors and that they may occur in men.
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