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  • Title: Neuropeptide Y stimulates prostacyclin production in porcine vascular endothelial cells.
    Author: Kawamura K, Smith TL, Zhou Q, Kummerow FA.
    Journal: Biochem Biophys Res Commun; 1991 Aug 30; 179(1):309-13. PubMed ID: 1883360.
    Abstract:
    We investigated the effects of neuropeptide Y on the prostacyclin production of cultured porcine aortic endothelial cells by measuring the stable metabolite of prostacyclin, 6-keto-prostaglandin F1 alpha, by radioimmunoassay. Neuropeptide Y induced dose- and time-dependent stimulation of prostacyclin production by cultured porcine aortic endothelial cells. The lowest stimulatory concentration of neuropeptide Y was 10(-8) M and maximal response, a 2.8 fold rise, was obtained with 10(-6) M. The stimulation lasted at least 24 h. The effect was associated with the stimulation of arachidonic acid release. Our data suggest that neuropeptide Y may inhibit the development of atherosclerosis by stimulating prostacyclin synthesis.
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