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  • Title: GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent.
    Author: Fridolf T, Ahrén B.
    Journal: Biochem Biophys Res Commun; 1991 Aug 30; 179(1):701-6. PubMed ID: 1883392.
    Abstract:
    We examined the Na(+)-dependency of the effects of GLP-1(7-36)amide in normal, overnight cultured rat islets. It was found that GLP-1(7-36)amide stimulated insulin secretion, 45Ca(2+)-efflux, and 86Rb(+)-efflux from prelabelled islets. All these effects were abolished by omitting Na+ from the medium and replacing it with N-methyl-glucamine. This suggests that GLP-1(7-36)amide stimulates insulin secretion by depolarizing the beta-cells by increasing their permeability to Na+.
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