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  • Title: Correlation of molecular orientation and packing density in a dsDNA self-assembled monolayer observable with surface-enhanced Raman spectroscopy.
    Author: Barhoumi A, Zhang D, Halas NJ.
    Journal: J Am Chem Soc; 2008 Oct 29; 130(43):14040-1. PubMed ID: 18834128.
    Abstract:
    Observations of two spectrally distinct ring breathing modes of guanine and adenine in the surface-enhanced Raman spectrum (SERS) of a dsDNA self-assembled monolayer on an Au nanoshell SERS substrate provide information concerning the orientation of its constituent molecules. The two modes vary with DNA concentration in a highly systematic manner, consistent with studies suggesting DNA molecules tend toward a more horizontal orientation at low-surface concentrations and a more vertical conformation at high concentrations. The introduction of small molecular spacers coadsorbed onto the Au nanoshell surface to "raise" the DNA molecules yields a SERS spectrum consistent with a more upright molecular orientation.
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