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  • Title: 3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication.
    Author: Iannazzo D, Piperno A, Romeo G, Romeo R, Chiacchio U, Rescifina A, Balestrieri E, Macchi B, Mastino A, Cortese R.
    Journal: Bioorg Med Chem; 2008 Nov 01; 16(21):9610-5. PubMed ID: 18835180.
    Abstract:
    A new class of compounds able to block the replication of subgenomic HCV RNA in liver cells is described. 3-Amino-2(5H)furanones 4 may be regarded as diketoacid analogues and were obtained by basic rearrangement of the isoxazolidine nucleus.
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