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  • Title: Measurement of trabecular bone microstructure does not improve prediction of mechanical failure loads at the distal radius compared with bone mass alone.
    Author: Lochmüller EM, Kristin J, Matsuura M, Kuhn V, Hudelmaier M, Link TM, Eckstein F.
    Journal: Calcif Tissue Int; 2008 Oct; 83(4):293-9. PubMed ID: 18839046.
    Abstract:
    Bone mass predicts a high proportion of variability in bone failure strength but is known to overlap among subjects with and without fractures. Here, we tested the hypothesis that trabecular bone microstructure, determined with micro-computed tomography (microCT), can improve the prediction of experimental failure loads in the distal forearm compared with bone mass alone. The right forearm and left distal radius of 130 human specimens were examined. Bone mineral density (BMD) was measured with peripheral dual energy X-ray absorptiometry (DXA). The specimens were mechanically tested to failure in a fall configuration, with the hand, elbow, ligaments, and tendons intact. Cylindrical bone samples from the metaphysis of the contralateral distal radius were obtained adjacent to the subchondral bone plate and scanned with microCT. When analyzing the total sample, BMD of the distal radius displayed a correlation of r = 0.82 with mechanical failure loads. After excluding 21 specimens with no obvious radiological sign of fracture after the test, the correlation increased to r = 0.85. When only including 79 specimens with loco typico fractures, the correlation was r = 0.82. The microstructural parameters showed correlation coefficients with the failure loads of < or =0.55 and did not add significant information to DXA in predicting failure loads in multiple regression models. These findings suggest that, under experimental conditions of mechanically testing entire bones, measurement of bone microstructure does not improve the prediction of distal radius bone strength. Determination of bone microstructure may thus be less promising in improving the prediction of fractures than commonly assumed.
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