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  • Title: A multicenter phase II trial of etoposide, methylprednisolone, high-dose cytarabine, and oxaliplatin for patients with primary refractory/relapsed aggressive non-Hodgkin's lymphoma.
    Author: Sym SJ, Lee DH, Kang HJ, Nam SH, Kim HY, Kim SJ, Eom HS, Kim WS, Suh C.
    Journal: Cancer Chemother Pharmacol; 2009 Jun; 64(1):27-33. PubMed ID: 18839172.
    Abstract:
    PURPOSE: We investigated the efficacy and toxicity of the etoposide, methylprednisolone, high-dose cytarabine, and oxaliplatin (ESHAOx), in which oxaliplatin (Ox) was substituted for cisplatin in the ESHAP [etoposide (E), methylprednisolone (S), high-dose cytarabine (HA), and cisplatin (P)] regimen, for patients with refractory/relapsed aggressive non-Hodgkin's lymphoma (NHL). MATERIALS AND METHODS: The ESHAOx consisted of E (40 mg/m(2) on days 1-4), S (500 mg on days 1-5), HA (2 g/m(2) on day 5), and Ox (130 mg/m(2) on day 1) every 3 weeks to a maximum of six cycles. Responses were assessed every three cycles. RESULTS: Twenty-seven patients were enrolled (19 with relapsed and 8 with refractory; 10 with an IPI score of 3-5). The overall response rate was 63% [95% confidence interval (95% CI) 45-81%], including eight complete remissions (CR) and one unconfirmed CR (33%). The median duration of response was 9.9 months (95% CI 5.7-14.2 months). After a median follow-up of 18.6 months, the median progression-free and overall survival was 5.3 months (95% CI 3.9-6.7 months) and 15.1 months (95% CI 9.4-20.9 months), respectively, with a 1-year survival rate of 61.5%. Most common grade 3/4 hematologic toxicities were neutropenia (56%) and thrombocytopenia (35%), whereas no patient experienced grade 3/4 renal or neurotoxicity. CONCLUSION: The efficacy and toxicity profiles suggested that the ESHAOx can be an alternative option for patients with refractory/relapsed aggressive NHL.
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