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  • Title: [Estrogen-like activity of 4-nonylphenol and bisphenol in immature SD rats].
    Author: Lu J, Cai D.
    Journal: Wei Sheng Yan Jiu; 2008 Jul; 37(4):413-6. PubMed ID: 18839522.
    Abstract:
    OBJECTIVE: To investigate the estrogen-like activity of 4-NP and BPA in the immature SD rats. METHODS: The vehicle, ethinyl estradiol (EE, 0.3 mg/kg, positive control), 4-NP (50 mg/kg, 100 mg/kg, 200 mg/kg), bisphenol (BPA, 200 mg/kg, 400 mg/kg, 600 mg/kg) were given orally (by gavage) q.d. to immature female Sprague-Dawley rats on the 21st, 22nd, 23rd postnatal days. The rats were sacrificed 24 hours after the last administration. Uterine wet weight, uterine/body weight ratio, height of the luminal epithelium, thickness of the myometrium and protein level of proliferating cell nuclear antigen (PCNA) of rat uterine were analysed by one-way ANOVA. RESULTS: In animal experiments, uterine wet weight and uterine/body weight ratio were significantly higher in the 4-NP 200 mg/kg and 100 mg/kg, BPA 600 mg/kg and 400 mg/kg (P < 0.05). Height of luminal epithelium, thickness of myometrium, as well as protein level of PCNA of rat uterine were significantly increased in the three groups of 4-NP, the three groups of BPA, and the mixture group (P < 0.05), and a dose-response relationship was observed. CONCLUSION: 4-NP and BPA had weak estrogen-like activities. They were the main environmental endocrine disruptors, and could influence the healthy of immature animals and children.
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