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  • Title: Arteriolar and venular capillary distribution in skeletal muscles of old rats.
    Author: Cui L, Ju Y, Ding L, Trejo-Morales M, Olfert IM.
    Journal: J Gerontol A Biol Sci Med Sci; 2008 Sep; 63(9):928-35. PubMed ID: 18840797.
    Abstract:
    Decreased skeletal muscle mass and proportion of fast-twitch glycolytic fibers are well-documented correlates of aging; however, data on concomitant changes on capillary-to-fiber ratio (C:F) are inconsistent. We simultaneously examined fiber-type composition and arteriolar and venular portions of capillaries in the distal hind-limb muscles of 12-, 24-, and 35-month old F1 hybrid F344 Brown Norway rats. Aging significantly increased C:F of venular capillaries in muscles, which also presented significant age-related increase in slow-(type I) and fast-(type IIa) oxidative fibers (plantaris, tibialis anterior, medial gastrocnemius; p<.05). In contrast, arteriolar and venular capillary proportions did not change in the soleus, extensor digitorum longus, or lateral gastrocnemius. These data suggest that age-associated increases in skeletal muscle capillarity may be due to the venular portion of capillaries and that the increase occurs primarily in muscles that demonstrate increased oxidative potential with age.
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