These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ethanol inhibits voltage-gated sodium channels in cultured superior cervical ganglion neurons.
    Author: Xiao Z, Lu Z, Liu Z, Liu W, Li L, Yin S, Yu S, Dong H, Zhu F.
    Journal: Neuroreport; 2008 Dec 03; 19(18):1773-6. PubMed ID: 18841087.
    Abstract:
    To determine whether actions on sodium channels contribute to ethanol's depressant effects on the autonomic nervous system, the acute effects of ethanol on Na+ currents in primary cultured superior cervical ganglion were examined by whole-cell patch clamp recordings. Ethanol inhibited Na+ currents concentration dependently, and decreased action potential firing. Ethanol (100 mM) did not affect activation curve, but resulted in a left shift of the inactivation curve and prolonged the recovery from inactivation. This finding indicates that the channels in the inactivated state are more susceptible to ethanol than those in the resting state. For the first time, this study demonstrates acute inhibitory effects of ethanol on sodium channel gating in sympathetic neurons.
    [Abstract] [Full Text] [Related] [New Search]