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  • Title: Correspondence of visual evoked potentials with FMRI signals in human visual cortex.
    Author: Whittingstall K, Wilson D, Schmidt M, Stroink G.
    Journal: Brain Topogr; 2008 Dec; 21(2):86-92. PubMed ID: 18841455.
    Abstract:
    Functional magnetic resonance imaging (FMRI) and event related potentials (ERPs) are tools that can be used to image brain activity with relatively good spatial and temporal resolution, respectively. Utilizing both of these methods is therefore desirable in neuroimaging studies to explore the spatio-temporal characteristics of brain function. While several studies have investigated the relationship between EEG and positive (+) BOLD (activation), little is known about the relationship between EEG signals and negative (-) BOLD (deactivation) responses. In this study, we used a visual stimuli designed to shift cortical activity from anterior to posterior regions of the visual cortex. Using EEG and FMRI, we investigated how shifts in +BOLD and -BOLD location were correlated to shifts in the N75 and P100 visual evoked potential (VEP) dipolar sources. The results show that the N75 dipole along with +BOLD, were indeed shifted from posterior to anterior regions of the visual cortex. The P100 VEP component, along with the -BOLD were not shifted to the same extent, indicating that N75 is better correlated to +BOLD than to -BOLD. These findings indicate how different components of the EEG signal are related to the positive and negative BOLD responses, which may aid in interpreting the relationship between visually evoked EEG and FMRI signals.
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