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  • Title: Microwave-induced thermoacoustic scanning CT for high-contrast and noninvasive breast cancer imaging.
    Author: Nie L, Xing D, Zhou Q, Yang D, Guo H.
    Journal: Med Phys; 2008 Sep; 35(9):4026-32. PubMed ID: 18841854.
    Abstract:
    A fast thermoacoustic computed tomography system with a multielement linear transducer array was developed to image biological tissues with circular scanning. The spatial resolution of the imaging system and the spectra of the thermoacoustic signals were analyzed. A modified integration backprojection algorithm using velocity potential was employed to recover the direct energy deposition distribution, signal processing methods, and reconstruction algorithms were validated by imaging a phantom. The differences of the microwave-frequency dielectric properties between malignant and normal adipose-dominated tissues in the breast are considerable, and the absorption contrast can reach as large as 6:1 at 1.2 GHz. An experiment of human breast tissue with a tumor was performed with this system; the thermoacoustic images reconstructed by a limited-field-filtered backprojection algorithm and a modified integration backprojection algorithm were also compared with a mammogram. Our results show that the system can provide a rapid and noninvasive approach for high-contrast breast cancer imaging.
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