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  • Title: Highly diastereoselective switchable enantioselective Mannich reaction of glycine derivatives with imines.
    Author: Yan XX, Peng Q, Li Q, Zhang K, Yao J, Hou XL, Wu YD.
    Journal: J Am Chem Soc; 2008 Nov 05; 130(44):14362-3. PubMed ID: 18841892.
    Abstract:
    Tuning of diastereoselectivity was realized in the Mannich reaction of glycine derivatives with aromatic and aliphatic N-Ts imines using CuClO4-FcPHOX ligand 4b and 4f having an MeO group at the 4-position and F atom at the 3,5-position of the phenyl ring on the P-atom respectively as catalyst, providing either anti- or syn-alpha,beta-diamino acid derivatives in high yields and in high diastereo- and enantioselectivities.
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