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  • Title: Potential nicotinic acetylcholine receptor ligands from 2,4-methanoproline derivatives.
    Author: Patel AB, Malpass JR.
    Journal: J Med Chem; 2008 Nov 13; 51(21):7005-9. PubMed ID: 18841955.
    Abstract:
    Potential nicotinic acetylcholine receptor (nAChR) ligands have been synthesized in which a methylisoxazole substituent is attached to the 1-position ( 26) of the 2-azabicyclo[2.1.1]hexane ring system or separated by "spacer" atoms ( 21 and 23). With ABT-594 as a model, a range of pyridine heterocycles have been attached to the 1-position via a -CH 2O- spacer ( 11, 14, and 6). The biological evaluation of target compounds showed there was no binding affinity at the alpha4beta2 and alpha3beta4 nAChR subtypes.
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