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  • Title: Antioxidant activity of N-carboxymethyl chitosan oligosaccharides.
    Author: Sun T, Yao Q, Zhou D, Mao F.
    Journal: Bioorg Med Chem Lett; 2008 Nov 01; 18(21):5774-6. PubMed ID: 18842408.
    Abstract:
    Three N-carboxymethyl chitosan oligosaccharides (N-CMCOSs) with different degrees of substitution (NA: 0.28, NB: 0.41, and NC: 0.54, respectively) were prepared by the control of the amount of glyoxylic acid in the etherification process of chitosan oligosaccharide (COS). Their antioxidant activities were evaluated by the scavenging of 1,1-diphenyl-2-picrylhrazyl radical (DPPH) radical, superoxide anion and determination of reducing power. With the increasing of substituting degree, the scavenging activity of N-CMCOSs against DPPH radical decreased and reducing power increased. As for superoxide anion scavenging, the order is NB>NC>NA. The difference may be related to the different radical scavenging mechanisms and donating effect of substituting carboxymethyl group.
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