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  • Title: Conditioned place preference produced by infusion of Met-enkephalin into the medial preoptic area.
    Author: Agmo A, Gómez M.
    Journal: Brain Res; 1991 Jun 07; 550(2):343-6. PubMed ID: 1884243.
    Abstract:
    The conditioned place preference procedure was used to evaluate the rewarding properties of D-Ala2-Met5-enkephalinamide (DALA) after bilateral infusion into the medial preoptic area. Doses of 60, 250 and 100 ng/cannula were used. It was found that all doses of DALA produced place preference. This suggests that the medial preoptic area is a structure where opioid reward is produced in doses as low as those required in already established reward systems. The significance of this in relation to sexual reward is discussed.
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