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  • Title: Intracellular dCTP/ara-CTP ratio and the cytotoxic effect of ara-C.
    Author: Kawasaki H, Kuwabara H, Hori H, Higashigawa M, Ohkubo T, Sakurai M.
    Journal: Cancer Invest; 1991; 9(4):409-13. PubMed ID: 1884247.
    Abstract:
    In this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.
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