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  • Title: Synthetic and biological studies on the spiro-mamakone system.
    Author: Murphy AC, Devenish SR, Muscroft-Taylor AC, Blunt JW, Munro MH.
    Journal: Org Biomol Chem; 2008 Oct 21; 6(20):3854-62. PubMed ID: 18843418.
    Abstract:
    An exploration of the chemistry of the spiro-mamakone system, exemplified by the cytotoxic, fungal metabolite spiro-mamakone A, is presented. The first reported synthesis of the spiro-mamakone carbon skeleton was achieved, as well as the synthesis of a variety of closely related analogues of the natural product. Biological testing of the synthetic analogues generated a structure-activity profile for the natural product, establishing the importance of the enedione moiety to biological activity.
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