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  • Title: [Predictive and prognostic markers of breast cancer. Molecular biological analysis of fixed tumor tissue].
    Author: Petry C, Gehrmann M, von Törne C, Weber K, Stropp U, Hennig G.
    Journal: Pathologe; 2008 Nov; 29 Suppl 2():181-3. PubMed ID: 18843491.
    Abstract:
    A multitude of prognostic and predictive multiparameter algorithms based on the analysis of mRNA have been published in recent years. Many of the algorithms require fresh or fresh frozen tissue as a source of the mRNA. However, practical considerations suggest formalin-fixed paraffin-embedded tissue (FFPE tissue) to be a more suitable starting material for routine diagnostic applications. Therefore, Siemens Healthcare Diagnostics is developing a fully automated method to extract mRNA and DNA from FFPE tissue for use in pathology laboratories. Initially, the method will be used as part of a prognosis assay to predict the likelihood of distant metastasis and death for node-negative breast cancer patients.
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