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  • Title: [The clinical characteristics of T cell large granular lymphocyte leukemia associated with pure red cell aplasia].
    Author: Zhou K, Wang HJ, Zhang L, Li HQ, Yang DL, Yan ZS, Jing LP, Wu YH, Chu YL, Zhang FK.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2008 May; 29(5):312-5. PubMed ID: 18844068.
    Abstract:
    OBJECTIVE: To analyze the characteristics of acquired pure red cell aplasia (PRCA) secondary to T cell large granular lymphocyte leukemia (T-LGLL). METHODS: Fourteen patients with T-LGLL associated with PRCA between 2000 and 2006 in our hospital were retrospectively analyzed. RESULTS: The median age at diagnosis was 61 years with equal gender distribution. The PRCA had indolent process, mainly presenting with anemia. Of the 14 patients, 9 had mild to moderate splenomegaly, one hepatomegaly and one lymphadenopathy. The median Hb level was 61.5 g/L and the median WBC count 4.3 x 10(9)/L. The median percentage and count of LGL in peripheral blood were 0.36 and 1.9 x 10(9)/L respectively. The median percentage of LGL in BM was 0.165 (0.085 - 0.410). Some patients had serologic abnormalities. All the 12 cases with available bone marrow cell cytogenetics showed normal karyotypes. With cyclosporine A or glucocorticoid immunosuppressive therapy, the overall response was 91%. CONCLUSION: T-LGLL was one of the major causes of acquired PRCA. This type of PRCA has the similar clinical and laboratory feature to that of other type of PRCA and has a good response to immunosuppressive therapy.
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