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  • Title: [The activating action of mercaptobenzimidazole derivatives on peritoneal macrophages].
    Author: Ratnikov VI, Ratnikova LI.
    Journal: Farmakol Toksikol; 1991; 54(2):57-9. PubMed ID: 1884800.
    Abstract:
    It was established that derivatives of mercaptobenzimidazole (bemitil, methoxybemitil, 5-ethoxy-2-ethylmercaptobenzimidazole hydrochloride) in a dose of 25 mg/kg stimulate the mouse peritoneal macrophages by increasing their phagocytic activity and phagocytosis index. Among the studied agents 5-ethoxy-2-ethylmercaptobenzimidazole hydrochloride possesses the greatest effect. The increase of phagocytosis processes was shown to be accompanied with a growth of the number of macrophages reducing nitroblue tetrazolium in diphormazan and with an enhancement of secretion of lysosomal enzymes.
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