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  • Title: Oxidant-responsive induction of the suf operon, encoding a Fe-S assembly system, through Fur and IscR in Escherichia coli.
    Author: Lee KC, Yeo WS, Roe JH.
    Journal: J Bacteriol; 2008 Dec; 190(24):8244-7. PubMed ID: 18849427.
    Abstract:
    The suf operon encoding a Fe-S assembly system is induced by peroxides through activators OxyR and IscR in Escherichia coli. For apo-IscR to bind, oxidation-mediated dissociation of Fur is required. Therefore, a peroxide-responsive signal is transduced through OxyR, IscR, and Fur to achieve oxidation-sensitive and maximal induction of this operon.
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