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  • Title: Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography.
    Author: Götzinger E, Pircher M, Geitzenauer W, Ahlers C, Baumann B, Michels S, Schmidt-Erfurth U, Hitzenberger CK.
    Journal: Opt Express; 2008 Oct 13; 16(21):16410-22. PubMed ID: 18852747.
    Abstract:
    We present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of the RPE: its depolarizing, or polarization scrambling effect on backscattered light. Two different segmentation algorithms are presented and discussed: a simpler algorithm based on retardation data, and a more sophisticated algorithm based on local variations of the polarization state calculated from averaged Stokes vector elements. By using a state of the art spectral domain PS-OCT instrument, we demonstrate the method in healthy and diseased eyes.
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