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  • Title: Prognostic factors in malignancy of the minor salivary glands.
    Author: Loh KS, Barker E, Bruch G, O'Sullivan B, Brown DH, Goldstein DP, Gilbert RW, Gullane PJ, Irish JC.
    Journal: Head Neck; 2009 Jan; 31(1):58-63. PubMed ID: 18853449.
    Abstract:
    BACKGROUND: The purpose of this study was to identify prognostic factors associated with minor salivary gland malignancies. METHOD: This was a retrospective study of 171 patients. Statistical analysis of both clinical and pathological parameters with survival outcomes was performed. RESULTS: Adenoid cystic carcinoma (46.8%), mucoepidermoid carcinoma (22.8%), and adenocarcinoma (18.7%) were the most common pathologies. The most frequent sites of primary tumor were in the oral cavity (44.4%) and nasal cavity (40.4%). The 5-year and 10-year overall survivals were 73.8% and 58.1%. Disease-specific survivals (DSS) were 78.2% and 66.7% and disease-free survivals (DFS) were 64.8% and 47.5%, respectively. Local recurrence rate was 26.9%, regional recurrence 7%, and distant failure was 18.7%. The grade of tumor was the only factor associated with DSS on multivariate analysis. CONCLUSION: Overall and DSS of minor salivary gland malignancies were good. Surgery, either alone or in combination with radiation, was an efficacious treatment modality. High-grade tumors were associated with worse DSF.
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