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  • Title: Malignant (fibrous) histiocytoma arising in association with a bone infarct in sicle-cell disease: coincidence or cause-and-effect?
    Author: Mirra JM, Gold RH, Marafiote R.
    Journal: Cancer; 1977 Jan; 39(1):186-94. PubMed ID: 188537.
    Abstract:
    A patient with homozygous-S sickle-cell disease complicated by malignant (fibrous) histiocytoma arising within a tibial medullary infarct is reported. This is the ninth reported case of human sarcoma associated with bone infarct and the first associated with sickle-cell disease. Evidence for a causal relationship is presented.
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