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  • Title: Treatment of erosive vulvovaginal lichen planus with methotrexate.
    Author: Jang N, Fischer G.
    Journal: Australas J Dermatol; 2008 Nov; 49(4):216-9. PubMed ID: 18855784.
    Abstract:
    We report the successful treatment of severe long-standing erosive vulvovaginal lichen planus in four adult female patients using 2.5-7.5 mg of oral methotrexate once weekly in conjunction with topical clobetasol dipropionate 0.05% ointment and tacrolimus 0.03-0.10% ointment. All cases experienced improvement in symptoms and healing of lesions within 4-8 weeks. Methotrexate was well tolerated and no adverse events have been observed in any of the patients at follow up 4-6 months later.
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