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  • Title: [Participation of histamine in activating the hypothalamo-hypophyseo-adrenal system during stress].
    Author: El'skiĭ VN.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1976 Sep; 62(9):1386-9. PubMed ID: 188693.
    Abstract:
    In 289 male rats, accumulation of histamine in diencephalon, augmentation of activity in the hypothalamus, and increase of the ACTH content in the hypophysis and 11-OCS in adrenal and plasma were revealed under a functional stress for the hypothalamo-hypophyseal-adrenal system (HHAS). Further accumulation of histamine was associated with increased secretion of CRF, ACTH, and 11-OCS. Blocking of histamine by diphenylhydramine hydrochloride (10.0 mg/kg i. p. -- 30 min before the experiment) depressed the rate and intensity of the initial reaction of HHAS activation.
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