These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mode of action of triethylenetetramine dihydrochloride on copper metabolism in Wilson's disease.
    Author: Siegemund R, Lössner J, Günther K, Kühn HJ, Bachmann H.
    Journal: Acta Neurol Scand; 1991 Jun; 83(6):364-6. PubMed ID: 1887758.
    Abstract:
    The drug of choice for the initial treatment of "decoppering" in Wilson's disease, an inherited disorder of copper metabolism, is the chelating agent D-penicillamine. In the case of harmful side-effects an alternative drug is triethylenetetramine dihydrocholoride (trien or trientine). Using the 24-h-urine excretion of copper and the oral copper loading test with copper-64, a double function for trien was found: trien increases the urine copper excretion and decreases the intestinal copper absorption respectively.
    [Abstract] [Full Text] [Related] [New Search]