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  • Title: Transport as a rate limiting step in glucose metabolism in virus-transformed cells: studies with cytochalasin B.
    Author: Bissell MJ.
    Journal: J Cell Physiol; 1976 Dec; 89(4):701-9. PubMed ID: 188839.
    Abstract:
    Steady-state kinetic tracer analysis and two-dimensional chromatography and autoradiography were used to examine the relation of glucose transport to its metabolism in cultured chick embryo fibroblasts. Cytochalasin B was added to Rous sarcoma virus-infected cells to bring the rate of glucose uptake to the level of uninfected cells. It is concluded for chick cells in culture that: (1) the transport of glucose, rather than its phosphorylation, is the rate limiting step and (2) the difference in aerobic glycolysis between normal and virus-transformed cells at physiological glucose concentration may be a consequence of the difference in the rates of glucose uptake.
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