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  • Title: [Changes in the subendothelial compartment during the maturation process of cerebral microvessels].
    Author: Bertossi M, Ribatti D, Mancini L, Virgintino D, Nico B, Quondamatteo F, Marzullo A, Roncali L.
    Journal: Boll Soc Ital Biol Sper; 1991 Feb; 67(2):159-66. PubMed ID: 1888482.
    Abstract:
    Basement lamina and pericytes of growing blood microvessels were analyzed in the chick embryo optic tectum, from the 8th incubation day to hatching. Formation of the basement lamina and morphological changes of the pericytes take place in a short range of time, but late in the embryonic life, when also the blood brain barrier (bbb) devices are developing. The spatial and temporal coincidence between basement lamina formation, endothelium tight junction differentiation, and perivascular arrangement of the astrocytic glia, indicates that these events are correlated and corroborates the hypothesis that the glia needs an extracellular matrix to induce the junctional system maturation in the neural endothelia. Pericytes are irregular in shape during the early neural angiogenesis and smooth and flattened later, as the basement lamina synthesis is taking place; these cells represent a second line of barrier beyond the endothelium when the bbb is immature, owing to their phagocytic and digestive properties.
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