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  • Title: Conformational interpretation of intramolecular electron transfer in Met5-enkephalins between Tyr and Met(S:.Br) radical.
    Author: Vesterman B, Bobrowski K, Betins J, Nikiforovich GV, Wierzchowski KL.
    Journal: Biochim Biophys Acta; 1991 Aug 09; 1079(1):39-42. PubMed ID: 1888763.
    Abstract:
    Mean distances between C beta atoms of redox centers and mean values of the exponentially distance dependent rate constants for intramolecular electron transfer, (k), in aqueous solution were calculated for Met5-enkephalin and its D-Ala2 analogue using the molecular mechanics and Monte Carlo techniques. The ratio of (k) values thus obtained proved similar to that determined experimentally for intramolecular electron transfer accompanying Met(S:.Br)----TyrO.radical transformation in these two peptides. This agreement indicates that the almost 2-fold difference observed between experimental k values for Met5-enkephalin and its D-Ala2 analogue can be attributed to the effect of Gly2 for D-Ala2 replacement on the average separation of the redox centers.
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