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  • Title: The effect of ranitidine, cimetidine or famotidine on low-dose post-prandial alcohol absorption.
    Author: Fraser AG, Prewett EJ, Hudson M, Sawyerr AM, Rosalki SB, Pounder RE.
    Journal: Aliment Pharmacol Ther; 1991 Jun; 5(3):263-72. PubMed ID: 1888825.
    Abstract:
    Plasma alcohol concentration following oral ingestion of 0.3 g/kg of alcohol (ethyl alcohol), one hour after an evening meal, was measured in four groups of 12 healthy subjects. Each group had a control study and a repeat study after 7 days dosing with either placebo or an H2-receptor antagonist (300 mg ranitidine nocte, 800 mg cimetidine nocte, or 40 mg famotidine nocte). There was no significant difference between the control and post-dosing studies in the integrated 4-h plasma alcohol concentration, peak plasma alcohol concentration, or time to reach peak alcohol concentration. This study shows that post-prandial alcohol absorption after 0.3 g/kg of alcohol is not affected by ranitidine, cimetidine or famotidine.
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