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  • Title: Bacteriophage formation without bacterial growth; the effect of iodoacetate, fluoride, gramicidin, and azide on the formation of bacteriophage.
    Author: PRICE WH.
    Journal: J Gen Physiol; 1947 Nov 20; 31(2):135-9. PubMed ID: 18896936.
    Abstract:
    1. Iodoacetate, fluoride, and azide have been found to prevent the formation of phage and to inhibit the synthesis of ATP by Staphylococcus muscae. It is suggested that energy-rich phosphate is needed for the synthesis of phage. 2. Gramicidin prevented the formation of phage. 3. No differences were found between normal bacteria and phage-infected bacteria in the inorganic phosphate, adenosinetriphosphate, ribonucleic acid, and desoxyribonucleic acid content of the cells. 4. The mechanism of phage formation is discussed.
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