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Title: [Estimation of glomerular filtration rate in children with chronic kidney disease (CKD) on the basis of cystatin C clearance]. Author: Sekowska R, Roszkowska-Blaim M. Journal: Pol Merkur Lekarski; 2008; 24 Suppl 4():61-4. PubMed ID: 18924505. Abstract: UNLABELLED: Glomerular filtration rate (GFR) is the best marker of renal function. Creatinine and cystatin C are accepted as endogenous parameters of GFR. THE AIM: Comparison between cystatin C clearance and other methods used for estimation of GFR. MATERIAL AND METHODS: The study group consist of 73 children mean age 12.26 +/- 4.18, with CKD stage 1-4. We determined clearance of creatinine using Schwartz formule (Cl(Sch)), Counahan-Barratt formule (Cl(C-B)), cystatin C clearance (Cl(cystC)) and referred them for nuclear clearance investigations--technetium-diethylenetriamine pentaacetic acid (Cl(99m)Tc-DTPA). RESULTS: Mean values of GFR (ml/min/1.73 m2) amounted to: Cl(Sch) 113.87 +/- 36.98; Cl(C-B) 84.74 +/- 29.73; Cl(cystC) 89.55 +/- 25.87; Cl(99m)Tc-DTPA 87.28 +/- 30.71. Significant correlations were found (p < 0.00001) between Cl(99m)Tc-DTPA and Cl(Sch) r = 0.72; Cl(C-B) r = 0.71 and Cl(cystC) r = 0.72. Receiver-operating characteristics analysis showed that there where no significant differences between these methods for estimation GFR. CONCLUSION: Cystatin C clearance is an alternative method for determination of GFR.[Abstract] [Full Text] [Related] [New Search]