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  • Title: Toxicity and activity of purified trichosanthin.
    Author: Ferrari P, Trabaud MA, Rommain M, Mandine E, Zalisz R, Desgranges C, Smets P.
    Journal: AIDS; 1991 Jul; 5(7):865-70. PubMed ID: 1892592.
    Abstract:
    Trichosanthin was purified from fresh Chinese root tubers of Trichosanthes kirilowii and evaluated for anti-HIV activity. Trichosanthin inhibited syncytium formation between infected H9 cells and uninfected Sup-T1 cells from 0.5 to 4 micrograms/ml. Trichosanthin also inhibited HIV replication in H9 and CEM-SS cells at 1 microgram/ml, but was toxic for MT-4 cells (HTLV-I-positive), at doses greater than 0.25 microgram/ml. This new purification procedure confirms the anti-HIV activity of trichosanthin on some cell lines in different biological assays.
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