These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Stereocontrolled total synthesis of amphidinolide X via a silicon-tethered metathesis reaction.
    Author: Rodríguez-Escrich C, Urpí F, Vilarrasa J.
    Journal: Org Lett; 2008 Nov 20; 10(22):5191-4. PubMed ID: 18928293.
    Abstract:
    Two esterifications and an RCM to create the challenging trisubstituted C12-C13 double bond were required in the total synthesis of amphidinolide X (1) reported here. Assembling the three fragments in this order, no RCM occurred or the process yielded mainly isomer Z. However, generating the E double bond first, by a new variant of a Si-tethered metathesis (using Schrock's catalyst), and carrying out the esterification and macrolactonization steps later, 1 was obtained exclusively.
    [Abstract] [Full Text] [Related] [New Search]