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  • Title: Expression of bone resorption regulators (RANK, RANKL, and OPG) in odontogenic tumors.
    Author: Andrade FR, Sousa DP, Mendonça EF, Silva TA, Lara VS, Batista AC.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Oct; 106(4):548-55. PubMed ID: 18928898.
    Abstract:
    OBJECTIVE: To investigate the expression of bone resorption regulators (receptor activator of nuclear factor kappa B [RANK], RANK ligand [RANKL], and osteoprotegerin [OPG]) in calcifying cystic odontogenic tumor (CCOT), adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), odontogenic myxoma (OM), and ameloblastic fibroma (AF). STUDY DESIGN: The expression of these mediators was evaluated by means of immunohistochemistry. RESULTS: All specimens demonstrated positive immunoreactivity to RANK, RANKL, and OPG. The quantification of these mediators in epithelium revealed a similar pattern of expression for RANKL and OPG in CCOT, AOT, CEOT, and AF. With regard to stromal/mesenchymal cells, the majority of AOT and CCOT cases showed a higher content of OPG than RANKL, whereas CEOT, OM, and especially AF had a tendency to present a greater content of RANKL than OPG. CONCLUSION: Our data indicate that the CCOT, AOT, CEOT, OM, and AF cell constituents express key regulators of bone metabolism that might locally modulate tumor-associated bone resorption.
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